Metabolic and Phenotypic Changes Induced during N-Acetylglucosamine Signalling in the Fungal Pathogen Candida albicans

The human commensal yeast Candida albicans is pathogenic and results in a variety of mucosal deep tissue problems when the host immunocompromised. exhibits enormous metabolic flexibility dynamic morphogenetic transition to survive under niche environmental conditions cause virulence. amino sugar N-acetylglucosamine (GlcNAc) available at infection sites, apart from acting as an extremely good carbon nitrogen source, also induces cellular signalling this pathogen. In C. albicans, GlcNAc performs multifaceted roles, including scavenging, import metabolism, (yeast—hyphae white—opaque switch), GlcNAc-induced cell death (GICD), Understanding molecular mechanism(s) involved processes has become main focus many studies. current study, we focused on changes associated with phenotypic changes. Here, employed gas chromatography–mass spectrometry (GC–MS), which high-throughput sensitive technology, unveil global metabolomic that occur vs. glucose grown cells. was analysed by high-resolution field emission scanning electron microscopy (FE-SEM). Metabolite analysis revealed upregulation metabolites glyoxylate pathway, oxidative fatty acid catabolism probably augment synthesis hypha-specific materials. Furthermore, GlcNAc-grown cells showed slightly more sensitivity amphotericin B treatment. These all together provide new insights into development antifungal therapeutics for control candidiasis humans.